Species Human Entrez 3021 | Human Mouse Ensembl ENSG00000132475 | |
Aliases H3F3B, H3.3B, H3 histone, family 3B (H3.3B) External IDs MGI: 1101768 HomoloGene: 134170 GeneCards: H3F3B | ||
H3 histone, family 3B (H3.3B) is a protein in humans that is encoded by the H3F3B gene.
Contents
Function
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
Gene
This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family. Unlike most histone genes, H3F3B is not located in a cluster, but rather is isolated in the telomeric region of chromosome 17.
Clinical significance
Somatic mutations in the H3F3B gene are associated with chondroblastoma. A rare de novo germline mutation of the H3F3B gene (A30P) has been linked to a syndrome with a range of developmental and behavioral abnormalities including microcephaly, mild strabismus, seizure disorder, autistic continuum, hypothyroidism, global developmental delay, and low muscle tone.