Guppy is a surname. Notable people with the surname include:
Darius Guppy, public school fraudsterEileen Guppy (1903–1980), British geologistHenry B. Guppy (1854–1926), British botanistHenry Guppy (librarian) (1861–1948), British librarianJohn Guppy (1874–1937), fisherman, farmer and political figure in NewfoundlandRobert John Lechmere Guppy (1836–1916), British naturalist; discoverer and namesake of the fishSarah Guppy (1770–1852), British inventorShusha Guppy (1935–2008), author, editor, singer and filmmakerSteve Guppy (born 1969), English retired footballer