Guppy is a surname. Notable people with the surname include:
Darius Guppy, public school fraudster
Eileen Guppy (1903–1980), British geologist
Henry B. Guppy (1854–1926), British botanist
Henry Guppy (librarian) (1861–1948), British librarian
John Guppy (1874–1937), fisherman, farmer and political figure in Newfoundland
Robert John Lechmere Guppy (1836–1916), British naturalist; discoverer and namesake of the fish
Sarah Guppy (1770–1852), British inventor
Shusha Guppy (1935–2008), author, editor, singer and filmmaker
Steve Guppy (born 1969), English retired footballer
