Guilfoyle is an Irish surname. It originates from Gaelic Mac Giolla Phoil, meaning "son (or descendant) of the follower of St. Paul". They were once a chief clan in Kings County, now known as Offaly.
The surname may refer to:
Brendan Guilfoyle (born 1984), Irish rugby league player
George Henry Guilfoyle (1913–1991), American prelate of the Roman Catholic Church who served as Bishop of Camden
Kimberly Guilfoyle (born 1969), American cable news personality
Margaret Guilfoyle (born 1926), British-born Australian Senator
Merlin Guilfoyle (1908–1981), American prelate of the Roman Catholic Church who served as Bishop of Stockton
Paul Guilfoyle (born 1949), American television and film actor
Paul Guilfoyle (actor born in 1902) (1902–1961), American stage, film, and television actor
Richard Thomas Guilfoyle (1892–1957), third Roman Catholic Bishop of Altoona
Ronan Guilfoyle (born 1958), Irish jazz musician
Tony Guilfoyle (born 1960), Irish actor
William Guilfoyle (1840–1912), Australian landscape gardener and botanist