Guignard is a surname. Notable people with the surname include:
Alexis Guignard, comte de Saint-Priest (1805–1851), French diplomat and historian
André Guignard, Swiss engineer initially educated as a watchmaker
Armand Charles Emmanuel Guignard, comte de Saint-Priest (1782–1863), French aristocrat
Christelle Guignard (born 1962), retired French alpine skier
Emmanuel Louis Marie Guignard, vicomte de Saint-Priest (1789–1881), French politician and diplomat during the Bourbon Restoration
François-Emmanuel Guignard, comte de Saint-Priest (1735–1821), French politician and diplomat during the Ancien Régime and French Revolution
Guillaume Emmanuel Guignard, vicomte de Saint-Priest (1776–1814), French émigré general who fought in the Russian army
Léon Guignard (1852–1928), French botanist and pharmacist
Jazz Guignard, popular Haitian jazz musician in the 1930s