Guignard is a surname. Notable people with the surname include:
Alexis Guignard, comte de Saint-Priest (1805–1851), French diplomat and historianAndré Guignard, Swiss engineer initially educated as a watchmakerArmand Charles Emmanuel Guignard, comte de Saint-Priest (1782–1863), French aristocratChristelle Guignard (born 1962), retired French alpine skierEmmanuel Louis Marie Guignard, vicomte de Saint-Priest (1789–1881), French politician and diplomat during the Bourbon RestorationFrançois-Emmanuel Guignard, comte de Saint-Priest (1735–1821), French politician and diplomat during the Ancien Régime and French RevolutionGuillaume Emmanuel Guignard, vicomte de Saint-Priest (1776–1814), French émigré general who fought in the Russian armyLéon Guignard (1852–1928), French botanist and pharmacistJazz Guignard, popular Haitian jazz musician in the 1930s