Guedes is a Portuguese surname. Notable people with the surname include:
Alexandre Guedes (born 1994), Portuguese footballerÁlvarez Guedes (1927–2013), Cuban comedian, actor, writer and businessmanBaltasar Guedes de Sousa, Captain-major of Portuguese CeylonBeto Guedes (born 1951), Brazilian singer-songwriterChristophe Guedes (born 1993), Swiss footballerDaniel Guedes (born 1994), Brazilian footballerFátima Guedes (born 1958), Brazilian singer and composerGonçalo Guedes (born 1996), Portuguese footballerHélder Guedes (born 1987), Portuguese footballerJoaquim Guedes (1932–2008), Brazilian architect and urban plannerMarcelo Antônio Guedes Filho (born 1987), Brazilian footballerMiguel Guedes (born 1972), Portuguese musicianPancho Guedes (born 1925), Portuguese architect, sculptor, and painterRita Guedes (born 1972), Brazilian actressRóger Guedes (born 1996), Brazilian footballerSérgio Guedes (born 1962), Brazilian footballer and manager