Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509. Guadinomine B is the most potent known inhibitor of the Type III Secretion System (TTSS) of Gram-negative bacteria. The guadinomine (gdn) biosynthetic gene cluster includes 26 open reading frames spanning 51.2 kb. Streptomyces sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.
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Guadinomine Wikipedia(Text) CC BY-SA