Grube is a surname. Notable people with the surname include:
Adolph Eduard Grube (1812–1880), Polish zoologist
Bruce Grube, 11th president of Georgia Southern University
Charles Grube (1904–1976), American football player
Chris Grube (born 1985), British sailor
Christian Grube (born 1934), German conductor
Ernst J. Grube (1932−2011), German historian of Islamic art and curator at the Metropolitan Museum of Art
Frank Grube (1905–1945), American baseball player
Franklin Grube (1831−1869), American physician and politician
George Grube (1899–1982), classicist
Henry Grube (died 1582), English politician
Janice Grube, American singer-songwriter
Jarrett Grube (born 1981), American baseball player
Nikolai Grube, German epigrapher
Rüdiger Grube (born 1951), engineer
Wilfried Grube (born 1923), German former field hockey player
Wilhelm Grube (1855–1908), German ethnographer
