Species Human Entrez 2689 | Human Mouse Ensembl ENSG00000136487 | |
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Aliases GH2, GH-V, GHL, GHV, hGH-V, GHB2, Growth hormone 2 External IDs HomoloGene: 128757 GeneCards: GH2 | ||
Growth hormone variant is a protein that in humans is encoded by the GH2 gene.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones, playing an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.