Groff is an anglicized form of the surname Graf or Graff and of predominantly Swiss and sometimes German origin. Notable people with the surname include:
Andrew Groff, American businessman and politician
Charles Wister Groff (1898–1987), American real estate developer and philanthropist
Jonathan Groff (born 1985), American actor
Lauren Groff (born 1978), American writer
Mike Groff (born 1961), American racing driver
Peter Groff (born 1963), American politician from Colorado
Richard F. "Regis" Groff (1935-2014), American politician from Colorado
Robbie Groff (born 1966), American racing driver
Ulysses Grant Groff (1865–1950), American landowner and philanthropist
Sarah True (née Groff, born 1981), American triathlete