Grissom is a surname.
People bearing it include:
Gus Grissom (1926–1967), the second American astronaut to fly in space; killed in the Apollo 1 accident
Lee Grissom (1907-1998), a former left-handed pitcher in Major League Baseball, active 1934-1941
Marv Grissom (1918-2005), a former pitcher in Major League Baseball
David Grissom (fl. from 1978), American session guitarist
Steve Grissom (born 1963), a NASCAR Busch Series driver and the 1993 Busch Series champion
Marquis Grissom (born 1967), a former Major League Baseball player; currently coach for the Washington Nationals
Eric Grissom (born 1974), a viral video producer and internet entrepreneur
Clayton Holmes Grissom (born 1978), American pop singer Clay Aiken, made famous by American Idol