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Grenada College was a college for women, founded by Baptists, in Grenada, Mississippi in 1851.
The college was founded in 1851 as the Yalobusha Female Institute. Its first president was Dr. W. S. Webb, who served until 1857. At first classes were held in the Union Hotel in Grenada, and also in the College Inn at 123 S. College Street. The college subsequently raised enough money for a building, which was completed by 1858.
The college closed during the American Civil War and its buildings were used for hospitals.
When it reopened, the college was known as the Emma Mercer Institute, and then Grenada Female College. Control of the college passed to the Methodist church in 1882, which renamed it Grenada College in 1884.
As of 1915, the college granted both Bachelor of Arts and Bachelor of Letters degrees, and had 13 faculty members.
In 1936, financial troubles led the church to close the school and transfer its assets to Millsaps College. The buildings were finally destroyed in the 1980s.