Grech is a surname of Maltese origin. Notable people with the surname include:
Alex Grech (born 1965), DJBrian Grech, photographerGodwin Grech, Australian Treasury official involved in the OzCar affairJoe Grech (born 1934), Maltese singerJoe Debono Grech (born 1939), politicianJoseph Grech (1948–2010), bishop of SandhurstKarin Grech (1962–1977), murder victimLeandro Grech (born 1980), football playerLino Grech (1930−2013), Romanian actor, writer and directorLouis Grech (born 1947), politicianMartin Grech, (born 1982), musicianProsper Grech, (born 1925), Maltese cardinalRic Grech (1946–1990), bassist