Glycosylphosphatidylinositol phospholipase D

Updated on Sep 30, 2024

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EC number 3.1.4.50 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 113756-14-2 BRENDA BRENDA entry KEGG KEGG entry

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase. This enzyme catalyses the following chemical reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H₂O ⇌ 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.

References

Glycosylphosphatidylinositol phospholipase D Wikipedia

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