Girish Mahajan (Editor)

Glycosylphosphatidylinositol diacylglycerol lyase

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EC number  4.6.1.14
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  129070-68-4
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) is an enzyme that catalyzes the chemical reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and two products, 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]. Other names in common use include (glycosyl)phosphatidylinositol-specific phospholipase C, GPI-PLC, GPI-specific phospholipase C, VSG-lipase, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and diacylglycerol-lyase (1,2-cyclic-phosphate-forming).

References

Glycosylphosphatidylinositol diacylglycerol-lyase Wikipedia


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