Symbol Glyco_hydro_61 InterPro IPR005103 Pfam structures | Pfam PF03443 CAZy GH61 PDB RCSB PDB; PDBe; PDBj | |
In molecular biology, glycoside hydrolase family 61 is wrongly classified as a family of glycoside hydrolases. In March 2013 it was re-classified as Auxiliary Activity 9 of the CAZy system.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
AA9 is known to be a copper dependent, oxidative enzyme able to cleave crystalline cellulose. Activity greatly depends on the presence of a divalent copper ion and a reductant such as gallate or ascorbate. The oxidative action of AA9 can work on either the reducing or the non-reducing end of glucose moietes. Although AA9 enzymes can be found in a large spectrum of biomass degrading fungi, research into this family is relatively new.