Rahul Sharma (Editor)

Glycoside hydrolase family 45

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Covid-19
Symbol  Glyco_hydro_45
Pfam clan  CL0199
PROSITE  PDOC00877
Pfam  PF02015
InterPro  IPR000334
SCOP  2eng
Glycoside hydrolase family 45

In molecular biology, glycoside hydrolase family 45 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Glycoside hydrolase family 45 CAZY GH_45 comprises enzymes with only one known activity; endoglucanase (EC 3.2.1.4). This family is also known as cellulase family K. The best conserved region in these enzymes is located in the N-terminal section. It contains an aspartic acid residue which has been shown to act as a nucleophile in the catalytic mechanism. This also has several cysteines that are involved in forming disulphide bridges.

References

Glycoside hydrolase family 45 Wikipedia


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