Girish Mahajan (Editor)

Glycineamide ribonucleotide

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Formula
  
C7H15N2O8P

Molar mass
  
286.18 g/mol

Glycineamide ribonucleotide httpsuploadwikimediaorgwikipediacommonsthu

Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis.

It is formed from phosphoribosylamine by the enzyme phosphoribosylamine—glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form FGAR.

GAR formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49)

Synonyms

Several names are associated with GAR:

  • 5'-p-Ribosylglycinamide
  • 5'-p-Ribosylglycineamide
  • 5'-Phosphoribosyl-glycineamide
  • 5'-Phosphoribosylglycinamide
  • 5'-Phosphoribosylglycineamide
  • Glycineamide ribotide
  • Glycinamide ribonucleotide
  • Glycineamide ribonucleotide
  • N(1)-(5-Phospho-D-ribosyl)glycinamide
  • N-Glycyl-5-O-phosphono-D-ribofuranosylamine
  • N1-(5-phospho-D-ribosyl)glycinamide

    • References

    Glycineamide ribonucleotide Wikipedia
    (Text) CC BY-SA