EC number 1.2.1.12 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9001-50-7 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NAD+, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, and glyceraldehyde-3-P-dehydrogenase. This enzyme participates in glycolysis / gluconeogenesis.
Structural studies
As of late 2007, 49 structures have been solved for this class of enzymes, with PDB accession codes 1A7K, 1B7G, 1CER, 1CF2, 1CRW, 1DBV, 1DC3, 1DC4, 1DC5, 1DC6, 1DSS, 1GAD, 1GAE, 1GD1, 1GGA, 1GPD, 1GYP, 1GYQ, 1HDG, 1I32, 1I33, 1IHX, 1IHY, 1J0X, 1K3T, 1ML3, 1NPT, 1NQ5, 1NQA, 1NQO, 1OBF, 1QXS, 1S7C, 1SZJ, 1U8F, 1VC2, 1YWG, 1ZNQ, 2B4R, 2B4T, 2DBV, 2EP7, 2G82, 2GD1, 2I5P, 3DBV, 3GPD, 4DBV, and 4GPD.