Glyceraldehyde 3 phosphate dehydrogenase (NAD(P) )

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (EC 1.2.1.59) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ ⇌ 3-phospho-D-glyceroyl phosphate + NAD(P)H + H⁺

The 4 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, NAD⁺, and NADP⁺, whereas its 4 products are 3-phospho-D-glyceroyl phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating). Other names in common use include (phosphorylating), triosephosphate dehydrogenase (NAD(P)), and glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).