EC number 2.3.2.5 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37257-21-9 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a glutaminyl-peptide cyclotransferase (EC 2.3.2.5) is an enzyme that catalyzes the chemical reaction
L-glutaminyl-peptideHence, this enzyme has one substrate, L-glutaminyl-peptide, and two products, 5-oxoprolyl-peptide and NH3.
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing). Other names in common use include glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, and glutaminyl-transfer ribonucleate cyclotransferase.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2AFM, 2AFO, 2AFS, 2AFU, 2AFW, 2AFX, 2AFZ, and 2IWA.
References
Glutaminyl-peptide cyclotransferase Wikipedia(Text) CC BY-SA