EC number 2.3.1.4 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9031-91-8 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a glucosamine-phosphate N-acetyltransferase (EC 2.3.1.4) is an enzyme that catalyzes the chemical reaction
acetyl-CoA + D-glucosamine 6-phosphateThus, the two substrates of this enzyme are acetyl-CoA and D-glucosamine 6-phosphate, whereas its two products are CoA and N-acetyl-D-glucosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase. Other names in common use include phosphoglucosamine transacetylase, phosphoglucosamine acetylase, glucosamine-6-phosphate acetylase, D-glucosamine-6-P N-acetyltransferase, aminodeoxyglucosephosphate acetyltransferase, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, N-acetylglucosamine-6-phosphate synthase, phosphoglucosamine N-acetylase, glucosamine-phosphate N-acetyltransferase, and glucosamine-6-phosphate N-acetyltransferase. This enzyme participates in glutamate metabolism and aminosugars metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1I12, 1I1D, 1I21, 2HUZ, and 2O28.