Neha Patil (Editor)

Gluconate dehydratase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
4.2.1.39

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
37290-75-8

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a gluconate dehydratase (EC 4.2.1.39) is an enzyme that catalyzes the chemical reaction

D-gluconate 2-dehydro-3-deoxy-D-gluconate + H2O

Hence, this enzyme has one substrate, D-gluconate, and two products, 2-dehydro-3-deoxy-D-gluconate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.

References

Gluconate dehydratase Wikipedia