Gluconate 2 dehydrogenase

In enzymology, a gluconate 2-dehydrogenase (EC 1.1.1.215) is an enzyme that catalyzes the chemical reaction

D-gluconate + NADP⁺ ⇌ 2-dehydro-D-gluconate + NADPH + H⁺

Thus, the two substrates of this enzyme are D-gluconate and NADP⁺, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP⁺ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.