Girdlestone is a surname. Notable people with the surname include:
Charles Girdlestone (1797–1881), English clergyman and biblical commentator
Cuthbert Girdlestone (1895–1975), British musicologist
Errol Girdlestone (born 1945), British music conductor
Gathorne Robert Girdlestone (1881–1950), English orthopaedic surgeon, son of Robert Baker Girdlestone
Robert Baker Girdlestone (1836–1923), English lexicographer, son of Charles Girdlestone
Thomas Girdlestone (1758–1822), British physician and writer
