The nature of the host-pathogen interaction between humans and Mycobacterium Tuberculosis is considered to have a genetic component. A group of rare disorders called Mendelian Susceptibility to Mycobacterial Diseases (MSMD) was observed in a subset of individuals with a genetic defect that results in increased susceptibility to Mycobacterial infection.
Genome-wide association studies
Early case and twin studies have indicated that genetic component are important in host susceptibility to Mycobacterial Tuberculosis. Recent Genome-wide association studies (GWAS) have identified three genetic risk loci, including at positions 11p13 and 18q11. As is common in GWAS, the variants discovered have moderate effect sizes.
References
Genetics of tuberculosis Wikipedia(Text) CC BY-SA