Geffen (Hebrew: גֶּפֶן, lit. Grapevine) is a Hebrew surname. Notable people with the surname include:
Aviv Geffen (born 1973), Israeli rock singer
David Geffen (born 1943), American record executive, film producer and theatrical producer
Maxwell M Geffen (1896-1980), American editor and publisher from New York
Sasha Geffen (born 1989), American writer and music critic from Boston
Shira Geffen (born 1971), Israeli actress, screenwriter and film director
Tobias Geffen (1870-1970), rabbi from Atlanta, Georgia
Yehonatan Geffen (born 1947), Israeli writer