Gascoyne-Cecil is a surname, and may refer to:
Georgina Gascoyne-Cecil, Marchioness of Salisbury (1827-1899), Lady of the Royal Order of Victoria and Albert
James Gascoyne-Cecil, 2nd Marquess of Salisbury (1791-1868), English Conservative politician
James Gascoyne-Cecil, 4th Marquess of Salisbury (1861-1947), Chancellor of the Duchy of Lancaster
Jonathan Hugh Gascoyne-Cecil (1939–2011), known as Jonathan Cecil, English theatre, film and television actor
Lord Edward Gascoyne-Cecil (1867-1918), British soldier and colonial administrator in Egypt
Robert Gascoyne-Cecil, 3rd Marquess of Salisbury (1830-1903), British statesman and Prime Minister
Robert Gascoyne-Cecil, 5th Marquess of Salisbury (1893-1972), prominent Tory politician
Robert Gascoyne-Cecil, 6th Marquess of Salisbury (1916-2003), Conservative Member of Parliament for Bournemouth West
Robert Gascoyne-Cecil, 7th Marquess of Salisbury (born 1946), Conservative politician
William Gascoyne-Cecil (1863-1936), Bishop of Exeter
