Gascoyne is a surname. Notable people with the surname include:
David Gascoyne (1916–2001), English poet associated with the Surrealist movement
Mike Gascoyne (b. 1963), British Formula One designer and engineer
Chris Gascoyne (b. 1968), English actor known for his role as Peter Barlow in the soap opera Coronation Street
Thomas Gascoyne (1876–1917), English professional cycling champion