Gargano is an Italian surname. Notable people with the surname include:
Andrea Gargano (1887–1970), Italian sport wrestler
Camillo Gargano (born 1942), Italian sailor
Francesco Gargano (1899–1975), Italian fencer
Johnny Gargano (born 1987), American professional wrestler
Margherita Gargano (born 1952), Italian middle-distance runner
Nicholas Gargano (1934–2016), English boxer
Reinaldo Gargano (1934–2013), Uruguayan politician
Walter Gargano (born 1984), Uruguayan footballer