Gandini is an Italian surname. Notable people with the surname include:
Antonio Gandini (1565–1630), Spanish Renaissance painterBrenda Gandini (born 1984), Argentine actress and modelErik Gandini (born 1967), Italian film directorEttore Gandini (born 1969), Italian footballerFranco Gandini (born 1936), Italian cyclistGerardo Gandini (1936–2013), Argentine composerGiorgio Gandini del Grano (died 1538), Italian painter of the Parma schoolJohn Gandini (born 1929), Australian trade unionistLen Gandini (born 1962), Australian rules footballerMarcello Gandini (born 1938), Italian automobile designerSaverio Gandini (1729–1796), Italian painter