Gamble is a surname. Notable people with the surname include:
Cheryl Gamble (born 1970), American singerChris Gamble (born 1983), American football playerClarence Gamble, heir of the Procter and Gamble soap company fortuneClarence Gamble (tennis player)David Gamble (film editor) (born June 24, 1955), British film editorDonte Gamble (born 1978), American football playerFred Gamble (racing driver) (born 1932), Formula One racerFred Gamble (actor) (1868–1939), actorJames Gamble (industrialist) (1803–1891), co-founder of Procter & GambleJames Sykes Gamble (1847–1925), botanistJim Gamble, British police officerJohn A. Gamble (1933–2009), Canadian politicianJohn M. Gamble (1791–1836), Officer in the United States Marine CorpsKenneth Gamble (born 1943), songwriter and producerMiriam Gamble (born 1980), poetNathan Gamble (born 1998), American child actorOscar Gamble (born 1949), former outfielder in Major League BaseballPeter Gamble (1790–1814), Officer in the United States NavyRyan Gamble (born 1987), Australian rules footballerWilliam Gamble (general) (1818–1866), Civil engineer and a Union cavalry officer in the American Civil WarWilliam Gamble (business) (1805–1881), Canadian businessman