Gamble is a surname. Notable people with the surname include:
Cheryl Gamble (born 1970), American singer
Chris Gamble (born 1983), American football player
Clarence Gamble, heir of the Procter and Gamble soap company fortune
Clarence Gamble (tennis player)
David Gamble (film editor) (born June 24, 1955), British film editor
Donte Gamble (born 1978), American football player
Fred Gamble (racing driver) (born 1932), Formula One racer
Fred Gamble (actor) (1868–1939), actor
James Gamble (industrialist) (1803–1891), co-founder of Procter & Gamble
James Sykes Gamble (1847–1925), botanist
Jim Gamble, British police officer
John A. Gamble (1933–2009), Canadian politician
John M. Gamble (1791–1836), Officer in the United States Marine Corps
Kenneth Gamble (born 1943), songwriter and producer
Miriam Gamble (born 1980), poet
Nathan Gamble (born 1998), American child actor
Oscar Gamble (born 1949), former outfielder in Major League Baseball
Peter Gamble (1790–1814), Officer in the United States Navy
Ryan Gamble (born 1987), Australian rules footballer
William Gamble (general) (1818–1866), Civil engineer and a Union cavalry officer in the American Civil War
William Gamble (business) (1805–1881), Canadian businessman
