Gambino is an Italian surname. Notable persons with that surname include:
Some members of the Gambino crime family, including:Carlo Gambino, New York mobster and former boss of the crime familyEmanuel Gambino, New York mobster and nephew of Carlo GambinoJohn Gambino, Sicilian mobster who operates in New JerseyRosario Gambino, Sicilian mobster imprisoned on drug chargesThomas Gambino, son of Carlo Gambino and caporegime in the Gambino crime familyBizzy Bone, or Gambino, one of the many aliases for rapper Byron McCaneChildish Gambino, stage name of actor Donald GloverLu Gambino, American football playerMike Gambino, college baseball coachSalvatore Gambino, Italian-German football player