Gamba is an Italian surname. Notable people with the surname include:
Danielle Gamba (born 1982), American model, dancer and NFL Cheerleader of Italian and Spanish descent
Enrico Gamba (1831–1883), Italian painter
Ezio Gamba (1958), Italian-Russian judoka and judo coach
Fran Gamba, 18th century Slovenian politician
Giuseppe Gamba (1857–1929), Cardinal of the Roman Catholic Church and an Archbishop of Turin
Piero Gamba (born 1936), Italian orchestral conductor and pianist
Marina Gamba (1570–1612), mother of Galileo Galilei's illegitimate children
Matteo Gamba (born 1979), Italian rally driver
Rumon Gamba (born 1972), English conductor
Sandro Gamba (born 1932), Italian basketball coach and player
Vincenzo Gamba (1606–1649), Italian musician, son of Galileo Galilei and Marina Gamba
