EC number 2.4.1.135 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9030-08-4 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase (EC 2.4.1.135) is an enzyme that catalyzes the chemical reaction
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylproteinThus, the two substrates of this enzyme are UDP-glucuronate and 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein, whereas its 3 products are UDP, 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-, and beta-D-xylosylprotein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xyl osyl-protein D-glucuronosyltransferase. Other names in common use include glucuronosyltransferase I, and uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V82, 1V83, 1V84, and 2D0J.