PubChem CID 5310985 Formula C19H20N2O2 3D model (Jmol) Interactive image | UNII 8S399XDN2K Molar mass 308.374 | |
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Synonyms 3-(2,4-dimethoxy-benzylidene)anabaseine |
GTS-21 (DMBX-A) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent.
Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.
References
GTS-21 Wikipedia(Text) CC BY-SA