Girish Mahajan (Editor)

GTS 21

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PubChem CID
  
5310985

Formula
  
C19H20N2O2

3D model (Jmol)
  
Interactive image

UNII
  
8S399XDN2K

Molar mass
  
308.374

GTS-21

Synonyms
  
3-(2,4-dimethoxy-benzylidene)anabaseine

GTS-21 (DMBX-A) is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent.

Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.

References

GTS-21 Wikipedia


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