EC number 2.7.11.1 Human Mouse | Species Human Entrez 2931 | |
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Aliases GSK3A, Gsk3a, 2700086H06Rik External IDs MGI: 2152453 HomoloGene: 88581 GeneCards: GSK3A | ||
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.
Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.
Model organisms
Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3atm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.