CAS Number 1253291-12-1 ChemSpider 27471591 3D model (Jmol) Interactive image | IUPHAR/BPS 6428 Formula C22H15F2N3O2 Molar mass 391.11 g/mol | |
 | ||
GRN-529 is a research drug that was developed by Wyeth as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5).
A study conducted by Pfizer found that GRN-529 reduced repetitive behaviors without sedation and partially increased sociability in mouse models of autism.
Another study conducted by Pfizer found a therapeutically relevant effect in animal models of depression. It is theorized to work by reducing glutamate receptor hyperactivity.
References
GRN-529 Wikipedia(Text) CC BY-SA