GRK6

G protein-coupled receptor kinase 6 is an enzyme that in humans is encoded by the GRK6 gene.

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. GRK6 appears to be involved in responses to morphine.