Species Human Entrez 2827 | Human Mouse Ensembl ENSG00000181773 | |
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Aliases GPR3, ACCA, G protein-coupled receptor 3 External IDs MGI: 101908 HomoloGene: 31303 GeneCards: GPR3 | ||
G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.
Function
GPR3 activates adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue. It has been proposed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands, however this result was not confirmed in a β-arrestin recruitment assay.
References
GPR3 Wikipedia(Text) CC BY-SA