Symbol GLYCAM1 HUGO 18023 UniProt Q8IVK1 | Entrez 644076 RefSeq XM_927461 Locus Chr. 12 q13.2 | |
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymph nodes. It is able to bind to the receptor L-selectin during inflammation, acting as a homing beacon for leukocytes expressing the receptor to enter the site of inflammation. GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.
References
GLYCAM1 Wikipedia(Text) CC BY-SA