Fyffe is a surname. Notable people with the surname include:
Jahmaal Fyffe (born 1990), English hip-hop rapper who has performed as Chip and as Chipmunk (rapper)
Jim Fyffe (1945–2003), American sportscaster and radio talk show host
Joseph P. Fyffe (1832–1896), American admiral
Nick Fyffe (born 1972), English musician
Will Fyffe (1885–1947), Scottish actor, singer, and songwriter