Fusco is an Italian surname. Notable people with the surname include:
Alfonso Maria Fusco, Italian Roman Catholic priest
Angela Fusco, Canadian actress
Angelo Fusco, Provisional Irish Republican Army member
Antonio Fusco, Italian professional football player
Brandon Fusco, American football player
C.J. Fusco, American writer
Coco Fusco, American artist
Cosimo Fusco, Italian actor
Daniel Fusco, lead pastor of Crossroads Community Church in Vancouver, WA
Emiliano Fusco, Argentine football midfielder
Gian Carlo Fusco, Italian writer, journalist, screenwriter and actor
Giovanni Fusco, Italian composer, pianist and conductor
Joe Fusco, American head football coach
John Fusco, American screenwriter
John Fusco (politician), American lawyer, jurist, and politician
Lionel Fusco, fictional character
Luca Fusco, Italian footballer
Maria Fusco, Belfast born writer, lecturer, art critic, and events organiser
Mark Fusco, American ice hockey player
Nicola Fusco, Italian mathematician
Onofrio Fusco, Italian professional football player and coach
Paul Fusco, American voice actor
Paul Fusco (photographer), American photojournalist
Raffaele Di Fusco, Italian professional football coach and a former player
Scott Fusco, American ice hockey player
Tarcisio Fusco, Italian composer of film scores
Blessed Tommaso Maria Fusco, Italian Roman Catholic priest