Froin's syndrome

Froin's syndrome – coexistence of xanthochromia, high protein level and marked coagulation of cerebrospinal fluid (CSF). It is caused by meningeal irritation (e.g. during spinal meningitis) and CSF flow blockage by tumour mass or abscess. Stagnation of the CSF within the thecal sac facilitates exudation from the tumour itself and activation of coagulation factors. Clinical test formerly used for evaluation of spinal stenosis was Queckenstedt's maneuver. Nowadays, an magnetic resonance imaging is applied. It often shows the prolongation of T1 and T2 signal in CSF caudal to a level of block. Phenomenon named after Georges Froin (1874–1932), a French physician who first described it.