Frizzell is a surname. Notable people with the surname include:
Alan Frizzell (born 1995), Scottish footballer
Andee Frizzell, actress
Colin Frizzell (born 1971), Canadian author of young adult novels
David Frizzell (born 1941), American Country Music Singer
David Frizzell (Indiana politician), Republican member of the Indiana House of Representatives
Dick Frizzell (born 1943), New Zealand artist
Gregory Kent Frizzell (born 1956), United States federal judge
Henry F. Frizzell (1839–1904), Union Army soldier and Medal of Honor recipient
Jimmy Frizzell (1937–2016), former Scottish association football player and manager
John Frizzell (born in Kingston, Ontario), Canadian screenwriter and film producer
John Frizzell (composer) (born 1966), American film and television composer
Lefty Frizzell (1928–1975), American country music singer, songwriter and exponent of honky tonk music
Mary Frizzell (1913–1972), Canadian athlete who competed in the 1932 Summer Olympics
William Frizzell (born 1962), former American football defensive back