Frenkel is a surname. Notable people with the surname include:
Alexander Frenkel (born 1985), German boxer of Ukrainian originDaan Frenkel (born 1948), Dutch computational physicistDanielle Frenkel (born 1987), Israeli high jumperEdward Frenkel (born 1968), mathematician and filmmakerHeinrich Frenkel (1860–1931), Swiss physicianIgor Frenkel (born 1952), Russian-American mathematicianJacob A. Frenkel (born 1943), Israeli economist and businessmanJames Frenkel (born 1948), American science fiction book editorNaftali Frenkel, 16-year-old killed in the 2014 kidnapping and murder of Israeli teenagersNaftaly Frenkel (1883–1960), Soviet officialPeter Frenkel (1939), East German race walkerRichard Frenkel (born 1966), patent lawyer, formerly with Cisco SystemsRina Frenkel (born 1956), Israeli politicianYakov Frenkel (1894–1952), Russian physicist, known for the Frenkel defectYan Frenkel (1920–1989), Soviet composerYitzhak Frenkel (1899–1981), Israeli painterHermann Frenkel (1850–1932), partner of the Jacquier and Securius Bank