Francke is a German surname. Notable people with the surname include:
August Hermann Francke (1663–1727), German Protestant theologian
Arne Francke (1904–1973), Swedish horse rider
Gloria Niemeyer Francke (1922–2008), American pharmacist and science writer
Kuno Francke (1855–1930), educator and historian
Malcolm Francke (born 1939), Australian cricketer
Master Francke (c.1380–1440), German painter
Michael Francke (1946–1989), Director of the Oregon Department of Corrections
Paul Francke (born 1979), American musician
Rend al-Rahim Francke (born 1949), Iraqi political activist and ambassador to the United States
