Francke is a German surname. Notable people with the surname include:
August Hermann Francke (1663–1727), German Protestant theologianArne Francke (1904–1973), Swedish horse riderGloria Niemeyer Francke (1922–2008), American pharmacist and science writerKuno Francke (1855–1930), educator and historianMalcolm Francke (born 1939), Australian cricketerMaster Francke (c.1380–1440), German painterMichael Francke (1946–1989), Director of the Oregon Department of CorrectionsPaul Francke (born 1979), American musicianRend al-Rahim Francke (born 1949), Iraqi political activist and ambassador to the United States