Francis is a French and English surname of Latin origin. Notable people with the surname include:
Alun Francis (born 1943), Welsh conductor
Anne Francis (1930-2011), was an American actress
Arlene Francis (1907-2001), American actress
Barrington Francis, Jamaican/Canadian boxer of the 1980s and '90s
Black Francis (born 1965), American Musician
Clare Francis (born 1946), British author
Connie Francis (born 1938), American pop singer
David Rowland Francis (1850–1927), American politician, Mayor of Saint Louis, Governor of Missouri, U.S. Secretary of the Interior
Damien Francis, (born 1979), English-born Jamaican footballer
Danusia Francis, (born 1994), British gymnast
Dick Francis (1920-2010), British jockey-turned-novelist
Eddie Francis, (born 1974), Canadian politician
Freddie Francis (1917-2007), English cinematographer and film director
Jane Francis, Winner of Polar Medal, 2002
Genie Francis (born 1962), Actress
Gerry Francis (born 1951), English footballer and manager
James Francis (1819-1884), Australian colonial politician
Jeff Francis, Major League Baseball pitcher
Joseph Francis (disambiguation), several people named Joe or Joseph Francis
Kay Francis (1905-1968), American actress
Kevin Francis (disambiguation), several people named Kevin Francis
K. T. Francis (1939–2013), Sri Lankan cricket umpire
Leigh Francis (born 1974), British comedian
Leslie Francis, American philosopher
Mark Francis (disambiguation)
Melissa Francis (born 1972), American television journalist and former child actress
Michael Kpakala Francis (1936–2013), Liberian Roman Catholic archbishop
Norman Francis (born 1931), President of Xavier University of Louisiana
Ranganathan Francis (born 1920), Indian hockey player
Robert Francis (barrister) (born 1950), British barrister specialising in medical law
Ron Francis (born 1963), Canadian professional ice hockey centerman
Roy Francis, British rugby league footballer and coach
Sage Francis (born 1977), hip-hop artist
Sam Francis, (1923-1994), American painter and printmaker
Sam Francis, American football player
Samuel Kensinger Francis, Fitness trainer
Samuel T. Francis (1947–2005), American columnist
Steve Francis (born 1977), American professional basketball player
Thomas Francis, Jr. (1900-1969), American physician, virologist, and epidemiologist
Trevor Francis (born 1954), English footballer