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Francesco "Franco" Zerafa (Maltese: Franġisk Zerafa, 1679 – 21 April 1758) was a Maltese architect. In 1714, he succeeded Giovanni Barbara as Capomastro delle Opere della Religione (the principal architect of the Order of St. John), a post which he held until his death.
He assisted Charles François de Mondion in the designs of Fort Manoel, and was responsible for major decorative additions at the palace of the Grand Master during the reign of Zondadari. Together with Antonio Azzopardi, he oversaw the construction of the Manoel Theatre to designs of Romano Carapecchia in 1731–32.
In 1757 he designed the Castellania in Valletta, but he died on 21 April 1758 before the building was completed. He was succeeded as Capomastro delle Opere by Giuseppe Bonici, who oversaw the construction of the Castellania until it was completed in 1760.